Cytotoxicity
Assays
Three stages involved in
lymphocyte-mediated cytotoxicity:
9 conjugate
formation
9 triggering
of membrane and cellular events
9 pore
formation in target cell membrane
Udirect
membrane-to-membrane contact between cytotoxic cell and target cell to form a conjugate
Uchanges
occur in cytotoxic cell with resulting producion of various cytokines and receptors
Uperforin
may cause pore formation
Ucytotoxic
cell may degranulate
