Monoclonal
Abs - 2
Definition:
emonoclonal antibodies are antibodies that
possess a single specificity
(idiotype) for a specific antigenic determinant (epitope)
Alternative name:
ehomogeneous antibodies
Techniques used to produce monoclonal
antibodies:
esomatic cell hybridization (cell fusion)
erecombinant DNA technique
Principle of monoclonal production by
somatic cell hybridization:
emonoclonal antibody production is based on
the fact that each member
of a B lymphocyte clone (daughter cells) will express the same idiotype throughout their life span
thus maintaining the
identical epitope specificity
