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- Immunohematology Applications
- Program for Clinical Laboratory Science
- Unit - 17
- ABO & H Blood Group System
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- Reading assignment:
- Study unit on Instructor’s website www.andrews.edu/AHLE/awm
- Learning objectives:
- 2. List the cells, body fluids, and secretions where ABO antigens can
be located.
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3
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- Learning objectives: continued
- 7. Compare and contrast the A1 and A2 phenotypes
with regard to antigen structure and serologic testing.
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4
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- Learning objectives: continued
- 12. Discuss the Bombay phenotype with regards to genetic pathway,
serologic reactions, and transfusion implications.
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6
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7
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- Antigens found on:
- All body fluids except spinal fluid
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- What is it:
- Type 1 – where the #1 C of D-galactose (Gal) is linked with the #3 C of
N-acetylglucosamine (Glc) (b1 3)
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- Type 2 – where the #1 C of D-galactose (Gal) is linked with the #4 C of
N-acetylglucosamine (Glc) (b1 4)
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- Two alleles:
- A glucosyltransferase called L-fucosyltransferase
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- The product of the A gene is:
- Attaches the sugar N-acetylgalactosamine (GalN) to H antigen
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- The product of the B gene is:
- Attaches the sugar D-galactose (Gal) to H antigen
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- The product of the O gene is:
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- Where the individual inherits both hh genes and lacks the H gene
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- Incidence:
- Only blood from another Bombay individual
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17
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- When red cells express differing number of red cell antigens and may
have qualitative differences as well.
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18
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- When is antiA1 formed:
- When there is a discrepancy between forward and reverse typing for ABO
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21
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22
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- In type A and type B individuals:
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25
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Notes
