Notes
Slide Show
Outline
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CLSC320
Principles of Immunology
  • Immunohematology Applications
  • Program for Clinical Laboratory Science
  • Unit - 18
  • Rh Blood Group System
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Unit – 17 Guidelines
  • Reading assignment:
  • Study unit on Instructor’s website www.andrews.edu/AHLE/awm
  • Learning objectives:
  • 2. Discuss the current genetic theory for the inheritance of Rh system antigens.
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Unit – 17 Guidelines
  • Learning objectives: continued
  • 7. Explain the test for weak D and the importance of an appropriate control.
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Historic Overview of Rh System
  • First discovered in:
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Rh Antigens & Antibodies
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Distribution of Rh Phenotypes
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General Characteristics of Rh Antigens
  • Where are antigens found:
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Rh Terminology
  • Fisher-Race (CDE terminology)
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Examples of Offspring
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Characteristics of Rh antibodies
  • About 80% of Rh negative patients who receive Rh positive red cells will develop anti-D.
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Weak D  (Du) antigen
  • When the D antigen is not detected using standard anti-D testing procedures.
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Unusual Rh Phenotypes
  • When all of the D antigens (D, C, E, c, e) are missing
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Hemolytic Disease of Newborn (HDN)
  • Become sensitized by having an Rh positive baby and either during pregnancy or at time of delivery some of the baby’s Rh positive red cells get into mother’s circulation.
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