Extravascular Hemolysis
Macrophage phagocytizes old or damaged RBC’s
Fe++
transferrin
Storage
(hemosiderin)
Or
Bone marrow
(ferritin)
Globin chains
Broken
down into individual
amino acids
which return to amino acid pool
Heme
Protophorphyrin
ring split open
in macrophage
to form
biliverdin
Bilirubin
released to circulation
