Intravascular Features
1. Accounts for 10% of aged cell destruction
2. Decreased levels of haptoglobin seen in plasma
3. Decreased levels of hemopexin seen in plasma
4. Methemoglobinemia
5. Methemoglobinuria
6. Colors associated with various hemoglobins:
Pink =
Free hemoglobin
Red =
Oxyhemoglobin
Brown =
Methemoglobin
7. Excess iron:
Stored as hemosiderin and ferritin
Excess iron filtered by renal glomerulus and absorbed by renal tubular cells
Hemosiderinuria results