Fibrinolysis - Mechanism
Mechanism:
Plasminogen
is activated to plasmin by:
Tissue Plasminogen Activators (TPA)
Urokinase: an “intrinsic” protein secreted by epithelial cells of
urinary tract – play very small role in hemostasis. Used primarily for therapeutic action
Plasminogen becomes bound to fibrin and is converted to plasmin
Plasmin
formed is capable of digesting:
Low molecular weight heparin (<17 units) binds AT and thrombin but does not inactivate
thrombin. Does inactivate Xa and other serine proteases
Fibrin polymers
Fibrinogen
Factors V and VIII
Secondary Fibrinolysis
Primary Fibrinolysis