ERYTHROPOIETIN - 1
History:
1878
– a feedback loop between the bone marrow and tissue was
postulated.
Early
1900’s – erythropoietin named as the hormonal agent that
stimulates erythropoiesis when tissue hypoxia exists.
1977
– erythropoietin isolated and tested.
1985
– erythropoietin gene is cloned.
1987
– recombinant erythropoietin available in Europe
1989
– FDA approves recombinant EPO.
1998
– recombinant EPO found in team competing in Tour de France