APOPTOSIS - 1
Definition:
Programmed
cell death
Depends
on the cross-binding of ligand FasL to red cell membrane
receptor Fas
High
levels of EPO protect cell against Fas & FasL cross-linking
and initiation of apoptosis
FasL
not found on earlier precursor cells
FasL
found only on polychromatophilic and orthochromatophilic
normoblasts
Process:
Fas
found on all red cell stages