Osmotic Balance
Process:
H2O
& anions (HCO3- & Cl-) pass freely thru membrane
Cation
pump regulates balance by moving Na+ &
K+ in and out of cell
Ca++ necessary for:
qMaintain cell integrity
qATPase activity of spectrin
qCalmodulin – a Ca++-binding
protein controls the calcium ATPase pump
Na+ =
1:12
K+ =
25:1
Intra vs extracellular
Results of
inbalance:
“colloid osmotic hemolysis” an intravascular hemolytic process
Sickle
cell anemia & Hereditary Spherocytosis