Phases of Anaerobic Glycolysis
1st phase:
Begins
with glucose and ends with glyceraldehyde-3-phosphate
Hexokinase
– lowest activity of all glycolytic enzymes
Hexokinase
requires Mg++
Hexokinase
deficiency inherited and causes hereditary nonspherocytic
hemolytic anemia (HNSHA)
2nd phase:
Begins
with glyceraldehyde-3-phosphate and ends with 3-phosphoglycerate
Both
the methemoglobin reductase pathway and the Rapaport-Luebering
pathway in this phase.
3rd phase:
Begins
with 3-phosphglycerate and ends with lactate
Pyruvate
kinase deficiency is inherited and is the most common
cause of HNSHA.