Globin Chain Synthesis - 2
Types of
globin chains seen in human fetuses:
epsilon
zeta
theta
e
z
t
Hemoglobinopathies
result when:
A
normal amino acid at a given position is replaced by a
different amino acid
HbS
=
6th of b chain has valine instead
of glutamic
acid
HbC
=
6th of b chain has lysine instead
of glutamic
acid
HbD
=
121st of b chain has glycine instead
of
glutamic acid