Globin Chain Synthesis - 3
Six genes
control types of globin chains formed:
e
z
t
On
chromosome 16
a
&
b
g
d
On
chromosome 11
Structure
and origin unknown
Synthesis of
globin chains follows:
Normal
protein synthesis in ribosomes. Review this process
from biology notes.
Regulation of
globin chain synthesis:
Rate
of DNA transcription to mRNA influenced by heme
levels
Increased
heme = increased globin chains
Levels of heme
and globin chains free in mature RBC’s:
Very
little