Hemoglobin synthesis Facts
Globin chains
loop to form cleft for heme to fit into.
Heme is
suspended between E and F helices.
Inside cleft
pocket amino acids are hydrophobic.
Hemoglobin
molecule is:
Spherical
in shape
Outside cleft
pocket amino acids are hydrophilic.
Has
4 heme molecules
Can
carry 4 oxygen molecules/hemoglobin molecule
Has
2 identical pairs of globin chains
All
adult hemoglobins have 2 alpha globin chains plus
2 other globin chains based on type of hgb:
Hgb A =
2a + 2b
Hgb A2 =
2a + 2d
Hgb F =
2a + 2g