Hemoglobin Assembly Facts
One alpha
chain joins with one non-alpha chain to form dimers.
Two dimers
join to form tetramers..
All adult
hemoglobins have 2 alpha globin chains plus 2 other globin
chains based on type of hgb:
Hgb
A =
2a + 2b
Hgb
A2 =
2a + 2d
Hgb
F =
2a + 2g
95 - 97%
2 - 3%
< 2% by age 2 years
Types of fetal
hemoglobins:
Hb
Gower 1 =
Hb
Gower 2 =
Hb
Portland =
2z + 2e
2a + 2e
2z + 2g