Hemoglobin Ontogeny
First 3 months
= alpha, zeta, and epsilon chains only.
Gamma chain
from 3 months to 1 year after birth.
Beta chains
begin prior to birth and reaches adult levels by 3 –
6 months post birth
Number of
genes regulating globin chain production:
a chains
=
b chains
=
g chains
=
d chains
=
4
2
4
2
z chains
=
e chains
=
2
2