Anemia of Chronic Disease - 2
Pathophysiology:
Role
of lactoferrin:
Sources:
Action:
macrophages
Granules of neutrophils
Outcompetes transferrin
for iron
Binds to lactoferrin
receptors on:
hepatocytes
RBCs lack receptors for
lactoferrin
Results:
Iron unavailable for
developing red blood cells
Role
of ferritin:
Binds
with iron and stores the iron