Sideroblastic Anemia - 3
Hematologic
impairment
Interferes
with porphyrin synthesis
Insertion of Fe++ into protophobilinogen IX b
inhibiting ferrochelatase – increased iron and protoporphyrin IX levels
measured by FFP & ZPP levels
Lead induced anemia:
Hematologic
blood smear picture:
Microcytic/hypochromic
anemia
Basophilic
stippling
Caused by lack of
breakdown of 5’ nucleotides and thus ribosomal RNA breakdown retarded
