Megaloblastic Anemia - 1
Definition:
A
hematologic disorder characterized by the production and
peripheral proliferation of immature, large, and dysfunctional
erythrocytes.
Etiology:
Root
cause:
Impaired
DNA synthesis
Deficiencies:
Vitamin
B12 (cobalamin)
Folate
(folic acid)
Role
of B12 and folate in DNA synthesis:
Vit
B12 role:
Acts as a cofactor in
transfer of methyl group from 5-methyltetrahydrofolate to homocysteine converting it
to methionine
folate role:
Folate needed for cycle to
supply tetrahydrofolate the methyl group acceptor