Vitamin B12 Deficiencies -3
Failure
to separate from haptocorrin
Lack
of intrinsic factor
Impaired absorption: continued
Impairment
of absorption:
Lack of trypsin due to
chronic pancreatic disease
Loss of parietal cells
via:
gastrectomy
Autoimmune
disease
Called
“pernicious anemia”
Blocking antibodies
(IF sites)
parietal cell
antibodies
90% +
70% +