Extravascular Hemolysis - C
Macrophage phagocytizes old or damaged RBC’s
Fe++
transferrin
Storage
(hemosiderin)
Or
Bone marrow
(ferritin)
Globin chains
Broken down into individual
amino acids which return to
amino acid pool
Heme
Protophorphyrin ring split
open in macrophage to form biliverdin
Bilirubin released to circulation