Extravascular Hemolysis - 2
Heme
reacts with heme oxygenase to form biliverdin + carbon
monoxide
Important facts:
Biliverdin
converted to bilirubin and then released into plasma where it
binds to albumin. It is now called indirect or
unconjugated bilirubin.
In
the liver the enzyme glucuronyl transferase conjugates
bilirubin with glucuronic acid to form conjugated bilirubin
(bilirubin diglucuronide) or (direct bilirubin)
In
hemolytic disorders the life span of red cell can be
shortened by 15 – 20 days without anemia seen
If
hemolytic disorders shortens the life span of red cell
more than 15 – 20 days anemia will be seen