Intravascular Hemolysis - 1
Accounts
for about 10% of red cell hemolysis.
Important facts:
Free
hemoglobin is in form of a/b
dimers
In
the liver the hemoglobin is broken down in same manner
as seen in extravascular hemolysis
When
haptoglobin is depleted the free hemoglobin is
converted to methemoglobin and binds to hemopexin
which can then enter hepatocytes
When
hemopexin is depeleted the methemoglobin binds to albumin which
keeps methemoglobin until hemopexin becomes available
The a/b
dimers bind to haptoglobin and go to liver