H. Spherocytosis - 1
Primary defect:
Spectrin:
Ankyrin:
Protein
4.2
Band
3
Europeans
& Americans
Japanese
Incidence:
Most
common inherited anemia in whites
1 in
every 5000 Europeans affected
220
in every million Americans affected
Mode of inheritance:
Autosomal
dominance:
Autosomal
recessive:
25%
75%
Only
seen in heterozygous state