H. Spherocytosis - 2
Results of defects:
Microspherocytes
Decreased
survival in spleen
Clinical and laboratory findings:
Anemia
Jaundice
Splenomegaly
Megaloblastic
crisis – due to folate deficiency
Increased
osmotic fragility
Positive
autohemolysis test with glucose correction
Increased
MCHC
Negative
Direct Antiglobulin Test (DAT)
Increased
indirect bilirubin
Increased
fecal urobilinogen
Erythroid
hyperplasia in bone marrow