H. Elliptocytosis
Primary defect:
a
& b Spectrin:
Protein
4.1
30 –
40% Europeans & Arabians
Incidence:
1 in
2000 – 4000 Americans
Seen
in all racial & ethnic groups
Mode of inheritance:
Autosomal
dominance:
Clinical types:
Common
HE
Spherocytic
HE
Stomatocytic
HE
Pyropoikilocytosis