H. Xerocytosis Features
Defect:
Increased
membrane permeability to K+
Component
deficiency unknown
Clinical features:
Loss
of K+ exceeds Na+ influx
Lab features:
stomatocytes
Target
cells
Decreased
osmotic fragility
Cells
dehydrate or shrivel up
Mild
to moderate hemolytic anemia
Increased
autohemolysis test uncorrected with glucose
Spiculated
red cells
macrocytes
Inheritance:
Elevated
MCHC
Rare
autosomal dominant