G6PD Deficiency Features - 2
G6PD variants:
Normal
G6PD
G6PD-B
G6PD-A+
G6PD-A-
African
descent
20-40%
have gene on X chromosome
Asn
replaced by Asp at 126th amino acid
Asymptomatic
normal activity
Asn
replaced by Asp at 126th amino acid
Additional
AA substitutions give 3 mutant forms of G6PD-A-
Most
common variant among whites
10-11% males are G6PD-A-69
G6PD-med
Class
III clinical features
Class
I clinical features
Kurdish
Jews have 3 – 50% incidence