PNH - 2
Defects cont’d:
This
is the only acquired hemolytic anemia caused by an
abnormality of cell membrane
Defective
gene:
Phosphatidylinositol,
class A (PIGA)
On
chromosome:
X chromosome
Specific
hematopoitic cell affected:
Cells
with increased susceptibility to lysis by complement
Pluirpotential
stem cell
Result
of defects: