PNH - 4
Classes of PNH cells:
Percentages
of PNH-III cells present:
Mild
hemolysis:
Perpetual
Hemoglobinuria & hemoglobinemia:
Episodic
hemolysis:
Cause of nocturnal hemoglobinuria and nocturnal
hemoglobinemia:
<20% PNH III cells
20 - 50% PNH III cells
>50% PNH III cells
As a
person sleeps the pH of blood becomes more acidic
and complement can be activated by acid pH
Incidence of nocturnal
hemoglobinuria and nocturnal hemoglobinemia:
%
positive for hemoglobinuria:
%
positive for hemoglobinemia:
25%
Almost
100%