TTP Features
Definition:
Thrombotic
thrombocytopenia purpura is a heterogenous clinical syndrome
with five distinct features:
TTP clinical features:
1. RBC fragmentation
2. thrombocytopenia
3. Fluctuating neurologic dysfunction
4. fever
5. Progressive renal failure
TTP miscellaneous features:
Disseminated
thrombotic occlusions of microcirculation
Deposition
of microthrombi containing platelets, fibrin, von
Willebrand factor in capillaries & arterioles