TTP Prognosis & Treatment
Prognosis:
70 –
90% remission with appropriate treatment
May
relapse months or years after treatment
Some
may have neurologic abnormalities persist
Most
patients recover completely
80%
respond after 2 – 3 units FFP
Remission
after 6 – 8 units FFP
Plasma
exchange therapy best
Treatment:
Plasma
exchange with anti-platelet agents:
Aspirin
Splenectomy
if severe conditions exist
While
in remission anti-platelet agents (6 mths or more)
Platelet
infusions not recommended
Dipyridamole,
sulfinpyrazone, etc.