Warm-Reactive AIHA - 3
Why extravascular hemolysis:
Antigens
on RBCs are spaced far apart so lysis can’t occur
so complement coated or antibody coated RBCs removed
by macrophages
Antibody
specificity in warm-reactive AIHA:
Anti-e
Anti-c
Anti-Scl
Anti-Wrb
Anti-Gerbich
Most
common antibody