Primary Cold-Reactive AIHA - 1
Alternate name:
Cold
agglutinin disease
Features
of cold agglutinin disease:
Chronic
Agglutination
occurs at 0 – 5oC
Age
of patient:
Complement
fixed at 20 – 25oC
Middle
age or elderly
Clinical
features of cold agglutinin disease:
Peripheral
vasocclusion when extremities exposed to cold
“acrocyanosis”
or Raynaud’s phenomena
Skin first turns white
Skin then turns blue
Numbness & pain
Compare
Raynaud’s phenomena with Raynaud’s disease
