PCH - 1
Definition:
Paroxysmal
Cold Hemoglobinuria
Incidence:
Extremely
rare
Massive
hemolysis after exposure to cold
Antibody
type:
Biphasic
IgG – attaches to RBCs at cold temp. and lysis RBCs at warm
temp.
Antigen
involved:
Clinical
features:
Also
called “Donath-Landsteiner” antibody
P
antigen
Complement
involvement:
C’
fixed to RBCs at low temp.