Drug-Induced Hemolytic Anemia
Types of Drug-Induced HA:
Immune Complex type:
Drug alone induces antibody formation
Antibody attaches to drug to form complex
Complex adsorbed unto RBCs and C’ fixed
Intravascular hemolysis occurs
Drugsinvolved:
quinidine
phenacetin
stibophen
DAT:
Negative unless drug is present
ASC:
Positive for only C3d/C3b
ASC = Antibody screen or indirect antiglobulin test