Drug-Induced HA - 2
Types of Drug-Induced HA:
Haptene
or Drug Adsorption type:
Drug
binds to RBCs
Antibody
formed to drug-RBC antigen complex
Antibody
attaches - C’ not usually fixed
Extravascular
hemolysis occurs
Drugsinvolved:
penicillin
cephalosporin
DAT:
Positive if tested using
drug sensitized RBCs
ASC:
Positive for IgG and maybe
C’