Drug-Induced HA - 3
Types of Drug-Induced HA:
Non-immunologic
Protein adsorption type:
Drug
alters RBCs membrane
Numerous
proteins (including IgG and C’) may attach to RBCs
Intravascular
and/or Extravascular hemolysis
Drugsinvolved:
cisplatin
cephalosporin
DAT:
Negative
ASC:
Positive for IgG and
C3d/C3b