Hemoglobinopathies - 1
Molecular abnormalities:
Single
amino acid substitution:
Double
amino acid substitutions:
Hb
S, Hb C, Hb E, Hb O-Arab, Hb M
Deletions
and/or insertions:
Hb
C-Harlem
Hb
Leiden
Fusion
of globin chains:
Hb
Lepore
beta chains abnormalities most common
Unstable
hemoglobins:
Increased
oxygen affinity hemoglobins:
Decreased
oxygen affinity hemoglobins:
Hb-Arruzzo, Hb-Crete
Hb-Kansas