Hb S – Features - 1
Increased hemoglobins with disease:
Hb
SS:
Hb
SC:
Increased
Hb F
Hb
S/bothal:
Increased
Hb F
Increased
Hb A2
Therapy:
Goal:
Increase
Hb F levels with hydroxyurea or butyrate therapy as 5 – 12% Hb
F may suppress severity of hemolysis and frequency of
episodes.
Pre-surgery:
Transfuse
with normal blood to lower Hb S below 50%