Hb C – Features
Amino acid substitution:
Glutamic acid by lysine
Trait:
Disease:
Incidence:
17 – 28% in West Africa
Hemoglobin scientific formula:
a2bb 6 glu - lys
a2b2 6 glu - lys
2 – 3% African American
Lab features:
Normocytic normochromic anemia
Increased codocytes
Tetragonal crystals
% Hb A in Hb CC:
0%
% Hb A in Hb C:
60%