Unstable Hemoglobins - 1
Globin chain abnormalities:
beta
chain
Most
common:
2nd most common:
Abnormalities:
Increased
oxygen affinity
Decreased
release of oxygen to tissues
Hemolytic
anemia, jaundice, splenomegaly
alpha
chain
Rarest:
gamma
and delta chains
Clinical
features:
Examples:
Hb-Koln
H-Zurich