Chromosomes of Thalassemia
Chromosome 16:
Alpha
(a) and zeta (z)
genes
Chromosome 11:
Beta
gene cluster
i.e. beta chain production is controlled by Beta
(b) gene
Globin chain
synthesis:
The
production of each type of globin chain is controlled by
it’s corresponding gene
Beta
(b), delta (d),
gamma (g), and epsilon (e)