Categories of Thalassemia
Beta thalassemias:
Decreased
production of beta globin chains
Other
globin chains affected:
ao:
delta
(d), gamma (g),
and epsilon (e)
no alpha chains produced
a+:
decreased alpha chains
a-thal-1:
Alpha
thalassemias:
Decreased
production of alpha globin chains
a-thal-2:
bo -thal:
b+-thal:
b++-thal:
dbo -thal:
no
beta chains produced
10-15%
beta chains produced
Mild
deficiency of beta chains
no
beta or delta chains produced
Hb-Lepore:
fusion
of delta-beta globin chains
HPFH:
Hereditary
persistence of fetal hemoglobin (Hb F)