a-Thalassemia - 2
Silent carrier:
Hb:
a+:
Hb-Barts = g4
Anemia:
mild
a-thal trait:
-a/-a
ao:
--/aa
Hb-Barts
= g4 (2-10%)
Hemoglobin-H
disease:
Hb-Barts
= g4 (10-40%)
then switches to:
Hb-H
= b4 (30-50%)
Hydrops
fetalis:
Hb-Barts
= g4 predominant
form
Hb-H
= b4 trace
amounts
Hb-Portland
= 5-20%
z2g2