Cancer Cryogenetics
Philadelphia
chromosome:
Translocation
of long arm of chromosome 9 and 22 [t(9;22)]
In
CML: 90% are positive for Philadelphia chromosome
In
ALL: 20% of adults and 2-5% of children are positive
In
AML: 1% are positive
T(8;21):
In
M2 (AML with maturation)
T(15;17):
In
M3 (Acute Promyelocytic Leukemia)
Note Table 30-1 on page 421 for other examples.