Acute Lymphoblastic Leukemia - 2
Treatment:
Childhood
ALL:
Methotrexate
results in megaloblastoid picture
It
acts as a folate antagonist
Rapidly
dropping WBC count
Temporary
paralysis may occur
Adult
ALL:
Daunorubican,
vincristine, prednisone
Bone
marrow transplant/peripheral stem cell collection
last option for relapsed or unresponsive ALL
Cardiac
complications
Abnormal
platelet function