FAB Classification of AML-2
M3:
Acute
Promyelocytic Leukemia accounts for 15% of AML
Two
types:
Hypergranular
M3
>30% are myeloblasts
and promyelocytes with heavy granulation
Numerous Auer rods seen
(faggot cells)
Very fine granulation
Cells
lack HLA-DR/a
Features of
both types
Cells
are strongly MPO/SBB positive
Microgranular
M3
Chromosome
translocation t(15;17)
Abnormal
retinoic acid (vitamin A) receptor
May
have D.I.C