FAB Classification of AML-6
M7:
Acute
Megalokaryocytic Leukemia 1% of AML cases
>30%
of marrow nucleated cells are blasts
30%
of the blasts are megakaryoblasts
Negative
for:
Sudan
Black B
Myeloperoxidase
a-naphthyl
butyrate esterase
a-naphthyl
acetate esterase
Antibodies
to glycoprotein IIb/IIIa
Positive
for:
Factor
VIII-related antigen
CD41,
CD42, or CD61
Preceded
by myeloproliferative disorder with pancytopenia and myelofibrosis
Children
<3 yrs or Down’s syndrome most frequent