CLINICAL FEATURES
CLL
CML
No
chromosomal abnormalities
Philadelphia
chromosome (Ph1)
Autoimmune
disorders may be seen
BCR-ABL
translocation
May
transform to:
Variable
course
Results
in activated tyrosine kinase production
Large-cell
lymphoma (Richter syndrome)
Blast
phase (L2-like blasts)
May
be confused with:
Small-cell
lymphoma
t(9;22)-22
goes to 9
Ph1 positive
= 2% in AML
Ph1 positive
= 5% in childhood ALL
Ph1 positive
= 20% in adult ALL
Ph1 negative
CML= CMmL
Chronic
phase:
Lasts
3 years
Accelerated
phase:
Fails
to respond to therapy
Blast
crisis phase:
>20%
blasts+promyelocytes in bm and pb
1/3
to ALL & 2/3 to AML